| 1 | Lionel Messi
FC Barcelona | FC Barcelona | 33 | 25 |
| 2 | Karim Benzema
Real Madrid | Real Madrid | 37 | 21 |
| 3 | Gerard Moreno
FC Villarreal | FC Villarreal | 35 | 18 |
| 4 | Luis Suárez
FC Barcelona | FC Barcelona | 28 | 16 |
| 5 | Raúl García
Athletic Club | Athletic Club | 35 | 15 |
| 6 | Lucas Ocampos
FC Sevilla | FC Sevilla | 33 | 14 |
| - | Iago Aspas
RC Celta | RC Celta | 37 | 14 |
| 8 | Ante Budimir
RCD Mallorca | RCD Mallorca | 35 | 13 |
| 9 | Álvaro Morata
Atlético Madrid | Atlético Madrid | 34 | 12 |
| 10 | Willian José
Real Sociedad | Real Sociedad | 37 | 11 |
| - | Roger
UD Levante | UD Levante | 36 | 11 |
| - | Santi Cazorla
FC Villarreal | FC Villarreal | 35 | 11 |
| - | Lucas Pérez
Alaves Vitoria | Alaves Vitoria | 34 | 11 |
| - | Jaime Mata
Getafe CF | Getafe CF | 34 | 11 |
| - | Joselu
Alaves Vitoria | Alaves Vitoria | 36 | 11 |
| - | Sergio Ramos
Real Madrid | Real Madrid | 35 | 11 |
| 17 | Ángel
Getafe CF | Getafe CF | 32 | 10 |
| - | Loren Morón
Betis Sevilla | Betis Sevilla | 36 | 10 |
| - | Maximiliano Gómez
FC Valencia | FC Valencia | 33 | 10 |
| - | Carlos Fernández
Granada CF | Granada CF | 34 | 10 |
| - | Mikel Oyarzabal
Real Sociedad | Real Sociedad | 37 | 10 |
| 22 | Alexander Isak
Real Sociedad | Real Sociedad | 37 | 9 |
| - | Luis Avila
Osasuna Pamplona | Osasuna Pamplona | 20 | 9 |
| - | Óscar Rodríguez
CD Leganés | CD Leganés | 30 | 9 |
| - | Antoine Griezmann
FC Barcelona | FC Barcelona | 35 | 9 |
| 26 | Arturo Vidal
FC Barcelona | FC Barcelona | 33 | 8 |
| - | Joaquín
Betis Sevilla | Betis Sevilla | 34 | 8 |
| - | Darwin Machís
Granada CF | Granada CF | 36 | 8 |
| - | Borja Mayoral
UD Levante | UD Levante | 34 | 8 |
| - | Youssef En-Nesyri
FC Sevilla | FC Sevilla | 18 | 8 |
| - | Rubén García
Osasuna Pamplona | Osasuna Pamplona | 30 | 8 |
| - | Fabián Orellana
SD Eibar | SD Eibar | 29 | 8 |
| - | Sergi Guardiola
Real Valladolid | Real Valladolid | 35 | 8 |
| - | Daniel Parejo
FC Valencia | FC Valencia | 35 | 8 |
| 35 | Ansu Fati
FC Barcelona | FC Barcelona | 24 | 7 |
| - | Enis Bardhi
UD Levante | UD Levante | 30 | 7 |
| - | Martin Braithwaite
FC Barcelona | FC Barcelona | 11 | 7 |
| - | Roberto Soldado
Granada CF | Granada CF | 33 | 7 |
| - | Portu
Real Sociedad | Real Sociedad | 35 | 7 |
| - | Antonio Puertas
Granada CF | Granada CF | 36 | 7 |
| - | Nabil Fekir
Betis Sevilla | Betis Sevilla | 32 | 7 |
| - | Roberto Torres
Osasuna Pamplona | Osasuna Pamplona | 36 | 7 |
| 43 | Karl Toko Ekambi
FC Villarreal | FC Villarreal | 18 | 6 |
| - | Charles
SD Eibar | SD Eibar | 30 | 6 |
| - | Kevin Gameiro
FC Valencia | FC Valencia | 29 | 6 |
| - | João Félix
Atlético Madrid | Atlético Madrid | 27 | 6 |
| - | Santi Mina
RC Celta | RC Celta | 34 | 6 |
| - | Luuk de Jong
FC Sevilla | FC Sevilla | 35 | 6 |
| - | Enes Ünal
Real Valladolid | Real Valladolid | 35 | 6 |
| - | Iñaki Williams
Athletic Club | Athletic Club | 38 | 6 |